Respiratory audio, such as coughing and breathing sounds, has predictive power for a wide range of healthcare applications, yet is currently under-explored. The main problem for those applications arises from the difficulty in collecting large labeled task-specific data for model development. Generalizable respiratory acoustic foundation models pretrained with unlabeled data would offer appealing advantages and possibly unlock this impasse. However, given the safety-critical nature of healthcare applications, it is pivotal to also ensure openness and replicability for any proposed foundation model solution. To this end, we introduce OPERA, an OPEn Respiratory Acoustic foundation model pretraining and benchmarking system, as the first approach answering this need. We curate large-scale respiratory audio datasets ($\sim$136K samples, over 400 hours), pretrain three pioneering foundation models, and build a benchmark consisting of 19 downstream respiratory health tasks for evaluation. Our pretrained models demonstrate superior performance (against existing acoustic models pretrained with general audio on 16 out of 19 tasks) and generalizability (to unseen datasets and new respiratory audio modalities). This highlights the great promise of respiratory acoustic foundation models and encourages more studies using OPERA as an open resource to accelerate research on respiratory audio for health.

Biosignals collected from wearable devices are widely utilized in healthcare applications. Machine learning models used in these applications often rely on features extracted from biosignals due to their effectiveness, lower data dimensionality, and wide compatibility across various model architectures. However, existing feature extraction methods often lack task-specific contextual knowledge, struggle to identify optimal feature extraction settings in high-dimensional feature space, and are prone to code generation and automation errors. In this paper, we propose DeepFeature, the first LLM-empowered, context-aware feature generation framework for wearable biosignals. DeepFeature introduces a multi-source feature generation mechanism that integrates expert knowledge with task settings. It also employs an iterative feature refinement process that uses feature assessment-based feedback for feature re-selection. Additionally, DeepFeature utilizes a robust multi-layer filtering and verification approach for robust feature-to-code translation to ensure that the extraction functions run without crashing. Experimental evaluation results show that DeepFeature achieves an average AUROC improvement of 4.21-9.67% across eight diverse tasks compared to baseline methods. It outperforms state-of-the-art approaches on five tasks while maintaining comparable performance on the remaining tasks.

Freezing-of-Gait (FoG) affects over 50% of mid-to-late stage Parkinson's disease (PD) patients, significantly impairing patients' mobility independence and reducing quality of life. FoG is characterized by sudden episodes where walking cannot start or is interrupted, occurring exclusively during standing or walking, and never while sitting or lying down. Current FoG detection systems require extensive patient-specific training data and lack generalization, limiting clinical deployment. To address these issues, we introduce FM-FoG, a real-time foundation model-based wearable system achieving FoG detection in unseen patients without patient-specific training. Our approach combines self-supervised pretraining on diverse Inertial Measurement Unit (IMU) datasets with sensor context integration. Since FoG occurs only during ambulatory activities, a lightweight CNN-LSTM activity classifier selectively activates the foundation model only during walking or standing, avoiding unnecessary computation. Evaluated on the VCU FoG-IMU dataset with 23 PD patients, FM-FoG achieves a 98.5% F1-score when tested on previously unseen patients, substantially outperforming competitive baseline methods. Deployed on a Google Pixel 8a smartphone, the system extends battery life by up to 72% while maintaining sub-20ms intervention latency. The results indicate that our FM-FoG can enable practical, energy-efficient healthcare applications that generalize across patients without individual training requirements.

Time series analysis has emerged as an important tool for improving patient diagnosis and management in healthcare applications. However, these applications commonly face two critical challenges: time misalignment and data sparsity. Traditional approaches address these issues through a two-step process of imputation followed by prediction. We propose MAGIC (Multi-tAsk Gaussian Process for Imputation and Classification), a novel unified framework that simultaneously performs class-informed missing value imputation and label prediction within a hierarchical multi-task Gaussian process coupled with functional logistic regression. To handle intractable likelihood components, MAGIC employs Taylor expansion approximations with bounded error analysis, and parameter estimation is performed using EM algorithm with block coordinate optimization supported by convergence analysis. We validate MAGIC through two healthcare applications: prediction of post-traumatic headache improvement following mild traumatic brain injury and prediction of in-hospital mortality within 48 hours after ICU admission. In both applications, MAGIC achieves superior predictive accuracy compared to existing methods. The ability to generate real-time and accurate predictions with limited samples facilitates early clinical assessment and treatment planning, enabling healthcare providers to make more informed treatment decisions.

Digital health analytics face critical challenges nowadays. The sophisticated analysis of patient-generated health content, which contains complex emotional and medical contexts, requires scarce domain expertise, while traditional ML approaches are constrained by data shortage and privacy limitations in healthcare settings. Online Health Communities (OHCs) exemplify these challenges with mixed-sentiment posts, clinical terminology, and implicit emotional expressions that demand specialised knowledge for accurate Sentiment Analysis (SA). To address these challenges, this study explores how Large Language Models (LLMs) can integrate expert knowledge through in-context learning for SA, providing a scalable solution for sophisticated health data analysis. Specifically, we develop a structured codebook that systematically encodes expert interpretation guidelines, enabling LLMs to apply domain-specific knowledge through targeted prompting rather than extensive training. Six GPT models validated alongside DeepSeek and LLaMA 3.1 are compared with pre-trained language models (BioBERT variants) and lexicon-based methods, using 400 expert-annotated posts from two OHCs. LLMs achieve superior performance while demonstrating expert-level agreement. This high agreement, with no statistically significant difference from inter-expert agreement levels, suggests knowledge integration beyond surface-level pattern recognition. The consistent performance across diverse LLM models, supported by in-context learning, offers a promising solution for digital health analytics. This approach addresses the critical challenge of expert knowledge shortage in digital health research, enabling real-time, expert-quality analysis for patient monitoring, intervention assessment, and evidence-based health strategies.

This paper presents a comprehensive analysis of the strategic imperative for healthcare organizations to develop proprietary foundation models rather than relying exclusively on commercial alternatives. We examine four fundamental considerations driving this imperative: the domain-specific requirements of healthcare data representation, critical data sovereignty and governance considerations unique to healthcare, strategic competitive advantages afforded by proprietary AI infrastructure, and the transformative potential of healthcare-specific foundation models for patient care and organizational operations. Through analysis of empirical evidence, economic frameworks, and organizational case studies, we demonstrate that proprietary multimodal foundation models enable healthcare organizations to achieve superior clinical performance, maintain robust data governance, create sustainable competitive advantages, and accelerate innovation pathways. While acknowledging implementation challenges, we present evidence showing organizations with proprietary AI capabilities demonstrate measurably improved outcomes, faster innovation cycles, and stronger strategic positioning in the evolving healthcare ecosystem. This analysis provides healthcare leaders with a comprehensive framework for evaluating build-versus-buy decisions regarding foundation model implementation, positioning proprietary foundation model development as a cornerstone capability for forward-thinking healthcare organizations.

Respiratory audio, such as coughing and breathing sounds, has predictive power for a wide range of healthcare applications, yet is currently under-explored. The main problem for those applications arises from the difficulty in collecting large labeled task-specific data for model development. Generalizable respiratory acoustic foundation models pretrained with unlabeled data would offer appealing advantages and possibly unlock this impasse. However, given the safety-critical nature of healthcare applications, it is pivotal to also ensure openness and replicability for any proposed foundation model solution. To this end, we introduce OPERA, an OPEn Respiratory Acoustic foundation model pretraining and benchmarking system, as the first approach answering this need. We curate large-scale respiratory audio datasets ( \sim 136K samples, over 400 hours), pretrain three pioneering foundation models, and build a benchmark consisting of 19 downstream respiratory health tasks for evaluation.

This study compares the performance of two open-source large language models (LLMs)-Llama3-70B and DeepSeekR1-distill-Llama3-70B-on six biomedical text classification tasks. Four tasks involve data from social media, while two tasks focus on clinical notes from electronic health records, and all experiments were performed in zero-shot settings. Performance metrics, including precision, recall, and F1 scores, were measured for each task, along with their 95% confidence intervals. Results demonstrated that DeepSeekR1-distill-Llama3-70B generally performs better in terms of precision on most tasks, with mixed results on recall. While the zero-shot LLMs demonstrated high F1 scores for some tasks, they grossly underperformed on others, for data from both sources. The findings suggest that model selection should be guided by the specific requirements of the health-related text classification tasks, particularly when considering the precision-recall trade-offs, and that, in the presence of annotated data, supervised classification approaches may be more reliable than zero-shot LLMs.

With the increasing prevalence of mental health conditions worldwide, AI-powered chatbots and conversational agents have emerged as accessible tools to support mental health. However, deploying Large Language Models (LLMs) in mental healthcare applications raises significant privacy concerns, especially regarding regulations like HIPAA and GDPR. In this work, we propose FedMentalCare, a privacy-preserving framework that leverages Federated Learning (FL) combined with Low-Rank Adaptation (LoRA) to fine-tune LLMs for mental health analysis. We investigate the performance impact of varying client data volumes and model architectures (e.g., MobileBERT and MiniLM) in FL environments. Our framework demonstrates a scalable, privacy-aware approach for deploying LLMs in real-world mental healthcare scenarios, addressing data security and computational efficiency challenges.

The application of AI in healthcare allows for the identification of complex patterns in patient data, improving diagnostic accuracy, treatment personalization, and operational efficiency [1]. Healthcare providers are increasingly leveraging predictive analytics to foresee health outcomes, enabling earlier interventions and more targeted care [2][26]. For instance, AI models have proven effective in identifying high-risk patients and optimizing preventive care strategies [3]. Diabetes, a major global health challenge, requires early detection and preventive care. Predictive models built using accessible tools like BigQuery ML can help healthcare professionals identify at-risk individuals efficiently. Cloud computing serves as a critical tool for AI and ML in healthcare, addressing many of the technical and infrastructural challenges associated with large-scale data analysis. With scalable infrastructure, cloud platforms allow healthcare providers to process and store vast amounts of data, facilitating AI-driven insights without the need of extensive on-site resources [4].